Sodium nitrite manufacturers remind you of the precautions of sodium nitrite as a cyanide antidote

Sodium nitrite manufacturers remind you of the precautions of sodium nitrite as a cyanide antidote

The product name of sodium nitrite used as cyanide antidote is sodium nitrite injection, and its main component is sodium nitrite. Sodium nitrite is colorless or white to slightly yellow crystal, odorless, slightly salty, hygroscopic, and the aqueous solution is alkaline. The precautions of sodium nitrite as cyanide antidote are as follows:

1. This product only temporarily delays its toxicity to cyanide poisoning, and still has the effect of dilating blood vessels. Cyanide has a high affinity with the ferric iron (Fe3 +) of the three-dimensional cytochrome oxidase, and when combined, it deactivates the enzyme, leading to poisoning and hypoxia. Sodium nitrite can restore enzyme activity, but cyanide toxicity will reappear after a few minutes.

2. When patients with cardiovascular and arteriosclerosis need to apply, the dosage should be appropriately reduced and the injection speed should be slowed down. Nitrosamine synthesized using this product has carcinogenic effects in animals, but has not been reported in humans. Injection of a larger dose of this product can cause cyanosis of high hemoglobin. Methylene blue can be used to reduce high hemoglobin. ,

3. Only temporarily delay the toxicity of cyanide poisoning. Immediately after using sodium nitrite, sodium thiosulfate was injected through the original intravenous needle to make it combine with CN- to become less toxic thiocyanate and excreted in the urine. It must be used in the early stage of poisoning. It will have no detoxification effect after a long time of poisoning.

4. Adverse reactions: nausea, vomiting, dizziness, headache, cold sweats, cyanosis, shortness of breath, fainting, hypotension, shock, convulsions. In addition to the excessive dose, the degree of adverse reactions is also related to the speed of injection of this product.

5. Sodium nitrite injection is a 3% aqueous solution, which is for intravenous use only, each time 10-20ml (ie 6-12mg / kg), 2-3ml per minute injection; half or full amount can be repeated after 1 hour if needed; In case of serious adverse reactions, the injection of this product should be stopped immediately.

6. Strictly grasp the amount of use: ① the amount commonly used by adults: 0.3 to 0.6g intravenously. ②Children's usual dose: According to body weight 6 ～ 12mg / kg.

The above are the matters needing attention for sodium nitrite as cyanide detoxification, even if it is bloated. I hope to help you who want to know this information. For more information about sodium nitrite, please visit our company website.